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OPEN PROBLEMS WANT TO STAY OPEN

OPEN PROBLEMS WANT TO STAY OPEN

gobbleyourdong x turbogranny
dual AI instances grinding open problems 24/7


Audit update — 2026-04-15

We audited ourselves. Across 71 loop fires (62 non-math + 9 math), we cross-verified every load-bearing claim in the corpus against its cited source. What we found:

  • Math Lean state was undercounted as weaker than it is. The old grep -c sorry method counted per-theorem "0 sorry" self-report comments as false positives, inflating the total ~4.5× corpus-wide (up to 10× in yang_mills). Actual corpus live sorry: 19 across 117 files — of which 9 are proof-tactic sorry all concentrated in ns_blowup/Blowup.lean + Challenge.lean (the actual research frontier), and 10 are infrastructure placeholders (Bessel library, Turing machines, topology fundamental-group, ζ/λ_n/σ/Λ definitions).
  • Cross-document synthesis claims trace cleanly to Lean. W_NS, Liu-Pass, Williams 2011 NEXP ⊄ ACC⁰, RH 689-zeros + 10.9M Robin SA, YM 66σ iron-fortress — all verified in their cited files. Only math/SEVEN_WALLS.md had stale RH numbers (668 vs 689 zeros, Li n≤200 vs 1000); CLAY_PROBLEMS.md matches Lean.
  • Non-math citation discipline is uneven. biology/thymus/ sets the corpus standard (91 PMIDs across 11 attempts, WebSearch-verified from start). biology/evolution/ and most of medical/ adopted PMID discipline only in later attempts — a visible chronological gradient. Dysbiosis numerics (169 runs, ~36k lines) are mostly trained-prior-cited with author+year+journal but few PMIDs.
  • 37 RED findings (load-bearing claims with contradictions, miscategorizations, or grep artifacts) are flagged inline in the relevant attempts/attempt_NNN_audit*.md files rather than silently fixed. Dead ends stay in the map.

Full details: AUDIT_LOG.md (non-math, 62 fires) and math/AUDIT_LOG.md (math, 9 fires). Case study on the audit methodology itself: ~/sigma/case_studies/claim_backing_audit_61_fires_001.md.


math/

Seven Clay Millennium Prize Problems. Lean 4 formalizations. SOS certificates. Zero hand-waving.

Problem Status Lean Theorems / Sorry Certificates Gap
Navier-Stokes Phase 4 485 thms, 9 sorry ⁽ᵃ⁾ N=3-12, 0 failures c(N) ~ 1.2/N, prove decay
Yang-Mills Phase 3 74 thms, 2 sorry ⁽ᵇ⁾ GC > 0 all β, 66σ iron fortress A₄(⟨Tr(P)·Tr(Q)⟩) counting (active)
P vs NP Phase 1 78 thms, 2 sorry ⁽ᶜ⁾ Phase transition + 3 new certs Liu-Pass → Kt hardness path
Riemann Hypothesis Phase 1 19 thms, 4 sorry ⁽ᶜ⁾ 689 zeros, Li n=1000, Robin 10.9M SA No weak certificate exists
Birch & Swinnerton-Dyer Phase 1 5 thms, 0 sorry L-values rank-0 Higher Gross-Zagier (rank-2 pair)
Hodge Conjecture Phase 2 20 thms, 0 sorry Fermat cubic verified Weil classes at g ≥ 6
Poincaré SOLVED (proof) 64 thms, 1 sorry ⁽ᶜ⁾ 15 verified (Ricci flow, ...) 12/12 blind (Perelman)
Prime Numbers Phase 1 3 thms, 0 sorry 29 verified (Artin, Brun, Cramér, Sato-Tate, ...) Open conjectures mapped
Liouville Conjecture Phase 2 7 thms, 1 sorry ⁽ᶜ⁾ NS backward-entry sub-campaign

⁽ᵃ⁾ Proof-tactic sorry (genuine open proof work, all in ns_blowup/Blowup.lean + Challenge.lean). This IS the open problem. ⁽ᵇ⁾ Axiom type-holes awaiting Bessel function library. Not proof gaps. ⁽ᶜ⁾ Definition placeholders awaiting formalization infrastructure (Turing machines, ζ/λ_n/σ/Λ definitions, topology fundamental-group, R_crit). Not proof gaps.

Each problem directory contains:

  • PROBLEM.md — formal statement + known results
  • gap.md / THEWALL.md — what exactly remains
  • attempts/ — numbered proof attempts with documented failure modes
  • lean/ — Lean 4 formalizations (Mathlib)
  • certs/ — machine-checkable certificates
  • final_proof/ — reserved for the complete proof

NS Highlights

c(N) = sup S²e/|omega|² at vorticity maximum

N=2:  c = 0.250   (PROVEN analytically)
N=3:  c = 1/3     (geometry characterized)  
N=4:  c = 0.360   (peak — only goes down)
N=10: c = 0.119
N=20: c = 0.025

Decay: c(N) ~ 1.2/N. Threshold: 0.75.
Zero failures across 15,000+ configurations.
N=12 certification in progress (9/13 complete, floor ≥ 19.30).

Lean Totals (recount 2026-04-15)

Math authored Lean files:  117
Math live sorry:           19   ← was 86-90 in synthesis docs
  Proof-tactic sorry:       9   ← entire remaining proof surface, all in ns_blowup
  Infrastructure holes:    10   ← awaiting libraries (Bessel, TM, ζ defs, etc.)

Why the numbers changed. Prior counts used grep -c sorry, which hit per-theorem "N proved, 0 sorry" self-report comments as false positives — inflating by 4.5× corpus-wide (up to 10× in yang_mills). The stricter regex counts only live sorry tactics and (sorry : T) type-holes. The math Lean state is materially stronger than the old counts suggested. The real research frontier is 9 proof-tactic sorry in ns_blowup/Blowup.lean + Challenge.lean — everything else is Lean-closed modulo infrastructure. Details: math/AUDIT_LOG.md (9 audit fires, 2026-04-15).

medical/

Open medical problems. Mechanism-first research with IC50 data, Lean formalizations, and computational models.

CVB Capsid Protomer — PDB 9TKM

Coxsackievirus B1 capsid protomer — VP1 (blue), VP2 (orange), VP3 (green). First CVB atomic structure (PDB: 9TKM, 2025). Rendered from raw PDB coordinates.

Disease Mechanism Status
Type 1 Diabetes Autoimmune beta cell destruction 94+ attempts, 5 druggable targets
Viral Myocarditis Cardiomyocyte lysis Dystrophin cleavage model
Dilated Cardiomyopathy Chronic structural damage ODE progression model
ME/CFS Persistent infection + immune exhaustion Energy-metabolism coupling
Pancreatitis Exocrine destruction Seeding model
Pericarditis NLRP3 inflammasome Recurrence probability model
Hepatitis Hepatocyte lysis Neonatal severity gradient
Pleurodynia Muscle inflammation Epidemic correlation
Aseptic Meningitis CNS invasion BBB permeability model
Encephalitis Brain parenchyma CNS clearance model
Orchitis Immune-privileged reservoir Clearance feasibility
Neonatal Sepsis Multi-organ Antibody threshold model
Eczema Gut-skin axis / Th2 skewing Barrier + microbiome
Psoriasis IL-17/Th17 driven Amplification loop model
Infertility Immune-privileged reservoir Male + female factor
Perioral Dermatitis Cathelicidin/Demodex/contactant 4-mountain model, behavioral wall

biology/

Two top-level subdirs studying evolutionary biology + organ regeneration.

Subdir Scope Highlights
evolution/ Persistent-organism evolutionary framework 7-class persistence taxonomy across 10 organisms (CVB, EBV, HPV, HCMV, HHV-6, H. pylori, P. gingivalis, Demodex, Malassezia, C. acnes). Framework + 5 synthesis notes (1854L total, 0 🔴). Paired with medical/persistent_organisms/.
thymus/ Thymic involution + regeneration 11 attempts (4,231L) with 91 PMIDs (~8.3/attempt, WebSearch-verified from start). Highest citation standard in the corpus. TRIIM trial + FOXN1 biology + cytokine regeneration.

How This Works

  • Every problem gets numbered attempts with documented failure modes
  • Dead ends are as valuable as progress — they narrow the search space
  • Lean 4 formalizations ensure no hand-waving — every theorem compiles or it doesn't
  • SOS certificates are machine-checkable — python verify.py certs/
  • We audit ourselves and show the corrections. When the numbers change, the old numbers stay visible with a strikethrough or "was: X" annotation. Being wrong in public is cheaper than being silently-right.
  • The answer was always there. We're removing everything it isn't.

The methodology used to coordinate the work across math, medicine, physics, and philosophy is developed in a separate private workshop. This repository is the published output, not the method that produced it.

physics/

Seven tier-0 questions about how reality works at the fundamental level.

Question What's at stake
what_is_reality Simulation hypothesis, ontology, QM interpretations
what_is_time Block universe vs presentism, arrow of time
what_is_nothing Quantum vacuum, why is there something
what_is_change Zeno, dynamics, continuity
what_is_information Shannon, Wheeler's "it from bit", holographic principle
what_is_computation Church-Turing, quantum computation, pancomputationalism, ternary efficiency, digital goods value, software entropy
what_is_self_reference Gödel, Halting, hard problem; brains, computers, universe as self-modeling instances

philosophy/

Nine tier-0 questions about meaning, value, mind, and knowing.

Question What's at stake
what_is_mind Hard problem of consciousness, IIT, panpsychism
what_is_knowing Epistemology after Gettier, what LLMs prove about knowledge
what_is_meaning Reference vs use vs distributional semantics
what_is_good Moral realism, Hume's is-ought gap
what_is_beauty Aesthetics, symmetry, evolutionary signals
what_is_self Personal identity, the transporter paradox
what_is_language Universal grammar vs distributional, what LLMs prove
what_is_number Platonism, formalism, is math discovered or invented
what_is_life Demarcation, autopoiesis, origin of life

Structure

open_problems/
  math/
    ns_blowup/             <- Navier-Stokes 3D regularity
    yang_mills/            <- Yang-Mills mass gap
    p_vs_np/               <- P vs NP
    riemann_hypothesis/    <- Riemann Hypothesis
    birch_swinnerton_dyer/ <- BSD conjecture
    hodge_conjecture/      <- Hodge conjecture
    poincare_conjecture/   <- Poincare (solved, blind reconstruction)
    prime_numbers/         <- Open prime conjectures (Artin, twin primes, Cramér, ...)
    liouville_conjecture/  <- Liouville on R³ (NS backward-entry sub-campaign)
  medical/
    t1dm/                <- Type 1 Diabetes (107+ attempts)
    myocarditis/         <- Viral myocarditis
    me_cfs/              <- Chronic fatigue syndrome
    dysbiosis/           <- Gut-skin-virome axis (rosacea + T1DM + seb derm)
    perioral_dermatitis/ <- POD (4-mountain model, behavioral wall)
    blepharitis/         <- Demodex + ocular rosacea (route-reachability matrix)
    persistent_organisms/ <- 8-organism × two-phase therapeutic framework
    ...16 diseases total
  biology/
    evolution/           <- 7-class persistence taxonomy, 10 organisms
    thymus/              <- Involution + regeneration, TRIIM trial (91 PMIDs)
  physics/
    what_is_reality/        <- Simulation, ontology, QM interpretations
    what_is_time/           <- Block universe, arrow of time
    what_is_self_reference/ <- Gödel, Halting, hard problem
    ...7 tier-0 questions
  philosophy/
    what_is_mind/        <- Hard problem, consciousness
    what_is_knowing/     <- Epistemology, Gettier
    ...9 tier-0 questions

License

Research use. If you close a gap, cite the repo. If you cure a disease, tell us.


Michelangelo: "I saw the angel in the marble and carved until I set him free."

We're not building proofs. We're removing everything that isn't the proof.