R package for estimating dim-light melatonin onset (DLMO) using the hockey-stick method
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Updated
Jun 9, 2026 - R
R package for estimating dim-light melatonin onset (DLMO) using the hockey-stick method
melafit: High-precision 24h melatonin profile analysis. Features bimodal skewed baseline cosine fitting (Van Someren & Nagtegaal, 2007) and a robust cost function (Gabel et al., 2017) for superior convergence, even with sparse data.
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Physiologically based pharmacokinetic-pharmacodynamic (PBPK/PD) model of oral melatonin with circadian oscillator coupling, virtual population simulation, and interactive Shiny app for personalized dosing.
A simple calculator for melatonin dosing for children, based on the recent International Pediatric Sleep Association and American Academy of Neurology guidelines.
Quick's (1974) photoreceptor pooling model — fitting melatonin suppression and PLR spectral sensitivities to multi-receptor models
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