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Wang-Cankun/README.md

Hi, I'm Cankun πŸ‘‹

πŸ“ Columbus, OH | 🧬 Biomedical AI Infrastructure

Building AI agent infrastructure for biomedical research β€” bridging LLMs, cloud computing, and multi-omics data at Ohio State's Comprehensive Cancer Center.

CV Google Scholar LinkedIn X

Selected Publications

LLM & AI Systems

  • A platform for the biomedical application of large language models β€” Nature Biotechnology 2025 doi

Disease-driven Computational Analysis

  • Common and divergent cellular aetiologies underlying HLHS and HRHS β€” European Heart Journal 2025 doi
  • Cell-free RNA signatures in maternal blood with fetal congenital heart disease β€” Circulation Research 2024 doi
  • Identifying intratumoral microbes from the ORIEN dataset β€” Cancer Research Communications 2024 doi β˜…
  • Abnormal progenitor cell differentiation in hypoplastic right heart syndrome β€” Circulation 2024 doi
  • Impaired human cardiac cell development due to NOTCH1 deficiency β€” Circulation Research 2023 doi β˜…
  • Microglia coordinate cellular interactions during spinal cord repair β€” Nature Communications 2022 doi
  • NIH SenNet Consortium to map senescent cells throughout the human lifespan β€” Nature Aging 2022 doi

Research Software & Databases

  • ssREAD: A single-cell and spatial RNA-seq database for Alzheimer's disease β€” Nature Communications 2024 doi β˜…
  • scGNN: A novel graph neural network framework for single-cell RNA-Seq β€” Nature Communications 2021 doi
  • IRIS3: Integrated cell-type-specific regulon inference server from scRNA-Seq β€” Nucleic Acids Research 2020 doi β˜…
  • scREAD: A single-cell RNA-Seq database for Alzheimer's disease β€” iScience 2020 doi β˜…

β˜… first or co-first author

What I Do

  • AI Agent Systems - RAG pipelines, knowledge graphs, LLM integration for biomedical research workflows
  • Cloud Infrastructure - Designing and managing HIPAA-compliant research computing platforms (AWS, Azure)
  • Multi-omics Analysis - Single-cell, spatial transcriptomics, and multi-omics data for cancer immunotherapy and neurodegenerative diseases
  • Full-stack Development - Research web applications, databases, and knowledgebases (Vue.js, NestJS, TypeScript, MySQL)

Background
  • MS Plant Science, South Dakota State University
  • BS Software Engineering, Beijing Jiaotong University
  • 7+ years building bioinformatics tools and cloud infrastructure at OSU
  • Pelotonia Institute for Immuno-Oncology, Ohio State Comprehensive Cancer Center

TypeScript Python R Vue.js NestJS FastAPI PyTorch MySQL Azure AWS Docker GitHub Actions Claude OpenAI

Pinned Loading

  1. OSU-BMBL/NOTCH1-cardiac-lineage-scRNAseq OSU-BMBL/NOTCH1-cardiac-lineage-scRNAseq Public

    Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency

    HTML 2 1

  2. OSU-BMBL/MEGA OSU-BMBL/MEGA Public

    a deep learning-based python package for identifying cancer-associated intratumoral microbes.

    Python 2

  3. OSU-BMBL/ssread OSU-BMBL/ssread Public

    A single-cell and spatial RNA-seq database for Alzheimer’s Disease

    Vue 27 8

  4. AI-notebooks AI-notebooks Public

    Some PyTorch Jupyter notebooks

    Jupyter Notebook