It would be great to calculate the TCR sequence diversity from the bulk RNAseq samples -- perhaps those tumors with a higher diversity of microbes have a correspondingly high diversity of TCRs.
TRUST and latest version TRUST4 (tutorial video) is a computational algorithm that can extract TCR/BCR immune repertoires from tumor bulk or single cell RNA-seq data. vv
It would be great to calculate the TCR sequence diversity from the bulk RNAseq samples -- perhaps those tumors with a higher diversity of microbes have a correspondingly high diversity of TCRs.
TRUST and latest version TRUST4 (tutorial video) is a computational algorithm that can extract TCR/BCR immune repertoires from tumor bulk or single cell RNA-seq data. vv