-
Notifications
You must be signed in to change notification settings - Fork 2
Expand file tree
/
Copy pathfeed.xml
More file actions
907 lines (772 loc) · 47.1 KB
/
Copy pathfeed.xml
File metadata and controls
907 lines (772 loc) · 47.1 KB
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
688
689
690
691
692
693
694
695
696
697
698
699
700
701
702
703
704
705
706
707
708
709
710
711
712
713
714
715
716
717
718
719
720
721
722
723
724
725
726
727
728
729
730
731
732
733
734
735
736
737
738
739
740
741
742
743
744
745
746
747
748
749
750
751
752
753
754
755
756
757
758
759
760
761
762
763
764
765
766
767
768
769
770
771
772
773
774
775
776
777
778
779
780
781
782
783
784
785
786
787
788
789
790
791
792
793
794
795
796
797
798
799
800
801
802
803
804
805
806
807
808
809
810
811
812
813
814
815
816
817
818
819
820
821
822
823
824
825
826
827
828
829
830
831
832
833
834
835
836
837
838
839
840
841
842
843
844
845
846
847
848
849
850
851
852
853
854
855
856
857
858
859
860
861
862
863
864
865
866
867
868
869
870
871
872
873
874
875
876
877
878
879
880
881
882
883
884
885
886
887
888
889
890
891
892
893
894
895
896
897
898
899
900
901
902
903
904
905
906
907
<?xml version="1.0" encoding="utf-8"?>
<feed xmlns="http://www.w3.org/2005/Atom" xml:lang="en">
<title type="text">phyletica</title>
<generator uri="https://github.com/jekyll/jekyll">Jekyll</generator>
<link rel="self" type="application/atom+xml" href="http://phyletica.org/feed.xml" />
<link rel="alternate" type="text/html" href="http://phyletica.org" />
<updated>2026-03-30T13:40:40-05:00</updated>
<id>http://phyletica.org/</id>
<author>
<name>Jamie Oaks</name>
<uri>http://phyletica.org/</uri>
<email>phyletica@auburn.edu</email>
</author>
<entry>
<title type="html"><![CDATA[Visiting Duke Center for Genomic and Computational Biology]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/duke-visit/" />
<id>http://phyletica.org/duke-visit</id>
<published>2022-11-09T00:00:00-06:00</published>
<updated>2022-11-09T00:00:00-06:00</updated>
<author>
<name>Jamie Oaks</name>
<uri>http://phyletica.org</uri>
<email>joaks@auburn.edu</email>
</author>
<content type="html">
<p>I just got back to Auburn after a fun visit to the
<a href="https://biostat.duke.edu/research/duke-center-genomic-and-computational-biology">Center for Genomic and Computational Biology</a>
at
<a href="https://duke.edu/">Duke University</a>
to give a seminar.
One of the highlights of the visit was spending time with the graduate students
of the Computational Biology &amp; Bionformatics Program.
They asked great questions after the seminar and at our lunch together.</p>
<p>Many thanks to CBB Ph.D. student <a href="https://www.devangthakkar.com/">Devang Thakkar</a>
for inviting me to speak and organizing my visit.</p>
<p>Here are the slides from my talk:</p>
<iframe src="//www.slideshare.net/slideshow/embed_code/key/8dwx5Mfs8EdeP1" width="595" height="485" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" style="border:1px solid #CCC; border-width:1px; margin-bottom:5px; max-width: 100%;" allowfullscreen=""> </iframe>
<div style="margin-bottom:5px"> <strong> <a href="//www.slideshare.net/jamieoaks7/generalizing-phylogenetics-to-infer-patterns-predicted-by-processes-of-diversification-254039437" title="Generalizing phylogenetics to infer patterns predicted by processes of diversification" target="_blank">Generalizing phylogenetics to infer patterns predicted by processes of diversification</a> </strong> from <strong><a href="//www.slideshare.net/jamieoaks7" target="_blank">Jamie Oaks</a></strong> </div>
<p><a href="http://phyletica.org/duke-visit/">Visiting Duke Center for Genomic and Computational Biology</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on November 09, 2022.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Tanner receives SSB GSRA award!]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/tanner-ssb-award/" />
<id>http://phyletica.org/tanner-ssb-award</id>
<published>2022-05-27T00:00:00-05:00</published>
<updated>2022-05-27T00:00:00-05:00</updated>
<author>
<name>Phyletica</name>
<uri>http://phyletica.org</uri>
<email>phyletica@auburn.edu</email>
</author>
<content type="html">
<h2 id="congrats-tanner">Congrats, Tanner!</h2>
<p>Congratulations to
Ph.D. student
Tanner Myers
for receiving the
<a href="https://www.systbio.org/graduate-student-research-awards.html">Graduate Student Research Award</a>
from the
<a href="https://www.systbio.org/">Society of Systematic Biologists</a>
to study (among other things) if a large chromosomal inversion reduces gene
flow along a hybrid zone between two lineages of fence lizards.</p>
<p><a href="http://phyletica.org/tanner-ssb-award/">Tanner receives SSB GSRA award!</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on May 27, 2022.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Claire receives STRI Fellowship!]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/claire-stri-fellowship/" />
<id>http://phyletica.org/claire-stri-fellowship</id>
<published>2022-01-25T00:00:00-06:00</published>
<updated>2022-01-25T00:00:00-06:00</updated>
<author>
<name>Phyletica</name>
<uri>http://phyletica.org</uri>
<email>phyletica@auburn.edu</email>
</author>
<content type="html">
<h2 id="congratulations-claire">Congratulations, Claire!</h2>
<p>Congratulations to
<a href="https://www.linkedin.com/in/claire-tracy-01a8a2225/">Claire Tracy</a>
for receiving a Short-Term Fellowship from the
<a href="https://stri.si.edu/">Smithsonian Tropical Research Institute</a>.
This will help support her research into the evolution of
tolerance to temperature fluctuations in damselfish.</p>
<p><a href="http://phyletica.org/claire-stri-fellowship/">Claire receives STRI Fellowship!</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on January 25, 2022.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Generalizing Bayesian phylogenetics to model shared divergences]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/generalized-phylo-preprint/" />
<id>http://phyletica.org/generalized-phylo-preprint</id>
<published>2021-10-18T00:00:00-05:00</published>
<updated>2021-10-18T00:00:00-05:00</updated>
<author>
<name>Jamie Oaks</name>
<uri>http://phyletica.org</uri>
<email>joaks@auburn.edu</email>
</author>
<content type="html">
<p>We are excited about some new work out of lab that relaxes an important
assumption in phylogenetics.
<a href="https://doi.org/10.1101/2021.07.23.453597">In a new bioRxiv preprint</a>,
<a href="https://perryleewoodjr.com/">Perry Wood, Jr.</a>,
<a href="https://cameronsiler.com/">Cam Siler</a>,
<a href="https://biodiversity.ku.edu/herpetology/people/brown">Rafe Brown</a>,
and I
describe how we generalize the space of trees in Bayesian phylogenetics to
avoid assuming divergences are independent across a phylogeny, and allow us to
infer shared divergences among multiple clades.
We have released
<a href="http://phyletica.org/ecoevolity">a new version of ecoevolity (Version 1.0.0)</a>
that implements this fully phylogenetic approach to inferring shared divergence
events across phylogenetic trees.</p>
<h2 id="the-assumption">The assumption</h2>
<p>In phylogenetics, we assume lineages diverge independently (conditional on the
topology) and only leave two descendant lineages (i.e., bifurcate).
Put another way, we assume all processes of diversification cause only a single
lineage to bifurcate, and have no affect on any of the other extant lineages
across the phylogeny.
Across the tree of life, there are likely many exceptions to this assumption.
For example, we can imagine rising sea levels fragmenting an island and
causing co-distributed species of lizards to diverge at the same time.</p>
<figure>
<a href="/images/phycoeval-preprint/slides-bifurcating.gif"><img src="/images/phycoeval-preprint/slides-bifurcating.gif" width="100%" /></a>
<figcaption>
<p class="figure-caption-box">
<span class="center-if-single-line">
Island fragmenetaion causing bouts of shared divergences.
</span>
</p>
</figcaption>
</figure>
<p>Instead of lizards on islands, let’s imagine three members of a gene family
residing along a region of a chromosome that gets duplicated.
This would create shared divergences across the phylogenetic history of the
gene family.
When multiple infected individuals spread a pathogen to others at a social
gathering, this will create shared divergences in the “transmission tree” of
the pathogen.
In fields as diverse as biogeography, genome evolution, and epidemiology, there
are interesting processes that violate the assumption of independent
divergences and cause shared divergences.</p>
<p>Back to our insular lizard example, we can also imagine
the rising sea levels fragmenting the island into more than
two islands, like in the animation below.
This will cause multifurcations
(a lineage diverging into three or more descendants)
in addition to shared divergences.</p>
<figure>
<a href="/images/phycoeval-preprint/slides-multifurcating.gif"><img src="/images/phycoeval-preprint/slides-multifurcating.gif" width="100%" /></a>
<figcaption>
<p class="figure-caption-box">
<span class="center-if-single-line">
Island fragmenetaion causing multifurcating, shared
divergences.
</span>
</p>
</figcaption>
</figure>
<p>Similarly, in epidemiology, when an infected individual spreads a pathogen to
two or more others at a social gathering, this will create a multifurcating
divergence in the transmission tree.</p>
<p>Current phylogenetic methods for inferring rooted trees assume all divergences
are independent and bifurcating.
More formally, if we have \(N\) tips, current methods only consider
trees with \(N-1\) independent, bifurcating divergences.
When shared or multifurcating divergences were common in the evolutionary
history of the system we want to study, such tree models are over-parameterized
as illustrated below.</p>
<figure>
<a href="/images/phycoeval-preprint/gecko-trees-flipped-cropped.svg"><img src="/images/phycoeval-preprint/gecko-trees-flipped-cropped.svg" width="100%" /></a>
<figcaption>
<p class="figure-caption-box">
<span class="center-if-single-line">
When shared or multifurcating divergences have occurred, current
phylogenetic models are over-parameterized.
</span>
</p>
</figcaption>
</figure>
<p>More importantly, by assuming all divergences are independent and bifurcating,
current phylogenetic methods do not allow us to test for patterns of shared or
multifurcating divergences predicted by processes of diversification that are
of interest across fields like biogeography, genome evolution, and
epidemiology.</p>
<h2 id="our-approach">Our approach</h2>
<p>To relax this assumption, we developed a Bayesian approach to generalizing the
space of tree models to allow for shared and multifurcating divergences
<a class="citation" href="#Oaks2021phycoeval">(Oaks <span style="font-style: normal">et al.</span>, 2022)</a>.
Under our generalized tree distribution,
trees with \(N - 1\) bifurcating divergences
are
only one class of tree models in a greater space of trees
with anywhere from from 1 to \(N - 1\) potentially shared
or multifurcating divergences.</p>
<figure>
<a href="/images/phycoeval-preprint/four-leaf-labeled-trees-boxed-highlight-shared-grid-cropped.png"><img src="/images/phycoeval-preprint/four-leaf-labeled-trees-boxed-highlight-shared-grid-cropped.png" width="100%" /></a>
<figcaption>
<p class="figure-caption-box">
<span class="center-if-single-line">
The rooted topologies considered by current phylogenetic methods (within
box) and the additional tree models considered by phycoeval's generalized
tree model.
The tree models with nonindependent (shared) divergences are highlighted in
orange.
</span>
</p>
</figcaption>
</figure>
<p>We developed reversible-jump Markov chain Monte Carlo algorithms to perform
inference across this generalized space of trees.</p>
<figure>
<a href="/images/phycoeval-preprint/phycoeval-rj-cartoon.png"><img src="/images/phycoeval-preprint/phycoeval-rj-cartoon.png" width="100%" /></a>
</figure>
<p>This allows us to jointly infer relationships, shared and multifurcating
divergences, and divergence times.</p>
<p>We coupled the generalized tree model with the “SNAPP likelihood”
<a class="citation" href="#Bryant2012">(Bryant <span style="font-style: normal">et al.</span>, 2012)</a>
for directly
calculating the probability of biallelic characters given a population (or
species) phylogeny, while analytically integrating over all possible gene trees
under a coalescent model and all possible mutational histories along those gene
trees under a finite-sites model of character evolution.
This allows us to tackle biogeographic questions by jointly inferring a species
tree and shared divergences from genomic data
<a class="citation" href="#Oaks2021phycoeval">(Oaks <span style="font-style: normal">et al.</span>, 2022)</a>.
However, the generalized tree distribution and associated algorithms are
independent of the likelihood function, and so can be used with other data
types and likelihood models (i.e., lots of room for future work and
applications!).</p>
<p>Using simulations, we found this approach consistently inferred shared and
multifurcating divergences with high support with moderately sized data sets.</p>
<figure>
<a href="/images/phycoeval-preprint/gecko-generalized-tree-pp-hist-cropped.svg"><img src="/images/phycoeval-preprint/gecko-generalized-tree-pp-hist-cropped.svg" width="100%" /></a>
<figcaption>
<p class="figure-caption-box">
<span class="center-if-single-line">
We simulated 100 data sets on the tree above. The histograms
show the posterior probabilities of correctly inferring the
shared and multifurcating divergences when analyzing all the
data sets under the generalized tree model.
</span>
</p>
</figcaption>
</figure>
<p>We applied this new approach to genomic data from two genera of geckos
co-distributed across the Philippines.
Fragmentations of the islands caused by interglacial rises in sea level predict
shared and multifurcating divergences over the last 5 million years.
Our results show support for this predicted pattern.</p>
<figure>
<a href="/images/phycoeval-preprint/gekko-phycoeval-cam-tree.svg"><img src="/images/phycoeval-preprint/gekko-phycoeval-cam-tree.svg" width="100%" /></a>
<figcaption>
<p class="figure-caption-box">
<span class="center-if-single-line">
Shared and multifurcating divergences inferred during the evolutionary history of
<i>Gekko</i> lizards across the Philippines.
From <a class="citation" href="#Oaks2021phycoeval">(Oaks <span style="font-style: normal">et al.</span>, 2022)</a>.
</span>
</p>
</figcaption>
</figure>
<figure>
<a href="/images/phycoeval-preprint/cyrt-phycoeval-cam-tree.svg"><img src="/images/phycoeval-preprint/cyrt-phycoeval-cam-tree.svg" width="100%" /></a>
<figcaption>
<p class="figure-caption-box">
<span class="center-if-single-line">
Shared and multifurcating divergences inferred during the evolutionary history of
<i>Cyrtodactylus</i> lizards across the Philippines.
From <a class="citation" href="#Oaks2021phycoeval">(Oaks <span style="font-style: normal">et al.</span>, 2022)</a>.
</span>
</p>
</figcaption>
</figure>
<p>If you want to learn more, here’s a talk I gave at the Evolution Meetings this summer:</p>
<iframe width="560" height="315" src="https://www.youtube.com/embed/1PX5Yz-Vgec" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen=""></iframe>
<p>And you can read our <a href="https://doi.org/10.1101/2021.07.23.453597">preprint here</a>.</p>
<p>This work was a lot of fun, but we have only scratched the surface with the
generalized tree distribution.
If you are interested in this work, please reach out; there’s so much more to
do!</p>
<h2 id="references">References</h2>
<ol class="bibliography"><li><span id="Oaks2021phycoeval">Oaks JR, Wood, Jr. PL, Siler CD, Brown RM. 2022. Generalizing Bayesian phylogenetics to infer shared evolutionary events. <i>Proceedings of the National Academy of Sciences</i> <span style="font-weight: normal">119</span>:e2121036119. DOI: 10.1073/pnas.2121036119.</span>
<a href="http://dx.doi.org/10.1073/pnas.2121036119">Link.</a>
</li>
<li><span id="Bryant2012">Bryant D, Bouckaert R, Felsenstein J, Rosenberg NA, Roychoudhury A. 2012. Inferring Species Trees Directly from Biallelic Genetic Markers: Bypassing Gene Trees in a Full Coalescent Analysis. <i>Molecular Biology and Evolution</i> <span style="font-weight: normal">29</span>:1917–1932. DOI: 10.1093/molbev/mss086.</span>
<a href="http://dx.doi.org/10.1093/molbev/mss086">Link.</a>
</li></ol>
<p><a href="http://phyletica.org/generalized-phylo-preprint/">Generalizing Bayesian phylogenetics to model shared divergences</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on October 18, 2021.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Gen-Phy at MIC-Phy]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/mic-phy/" />
<id>http://phyletica.org/mic-phy</id>
<published>2021-02-26T00:00:00-06:00</published>
<updated>2021-02-26T00:00:00-06:00</updated>
<author>
<name>Jamie Oaks</name>
<uri>http://phyletica.org</uri>
<email>joaks@auburn.edu</email>
</author>
<content type="html">
<p>The 2021 Mathematical, Inferential, and Computational Phylogenomics (MIC-Phy)
meeting was great. Lots of great
<a href="https://mrborges23.github.io/micphy2021/posters">posters</a>,
<a href="https://mrborges23.github.io/micphy2021/talks">talks</a>
and
<a href="https://mrborges23.github.io/micphy2021/workshop">workshops</a>.
I was only bummed about the talks I missed due to the difference in time zones.
But, luckily, most of the
<a href="https://mrborges23.github.io/micphy2021/program">talks are now up online</a>,
so I’m eager to catch up on what I missed.</p>
<p>I presented some new work by
<a href="https://perryleewoodjr.com/">JR</a>
and I,
where we generalized the space of trees explored during Bayesian phylogenetic
inference in order to infer shared and multifurcating divergences.
Based on simulations, the new approach can accurately infer such
branching patterns from genomic data.
Equally important, it does not spuriously support such patterns when
divergences are independent and bifurcating.
Using this approach, we found evidence for the signature of interglacial rises
in sea levels fragmenting the Philippine Islands in the phylogenies of two
genera of geckos.</p>
<p>You can find our
<a href="/slides/mic-phy-2021.pdf">slides here</a>
and the video below.</p>
<iframe width="560" height="315" src="https://www.youtube.com/embed/4xzcrkYyriU" title="YouTube video player" frameborder="0" allow="accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture" allowfullscreen=""></iframe>
<p><a href="http://phyletica.org/mic-phy/">Gen-Phy at MIC-Phy</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on February 26, 2021.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Holden joining the USGS]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/holden-usgs/" />
<id>http://phyletica.org/holden-usgs</id>
<published>2020-09-01T00:00:00-05:00</published>
<updated>2020-09-01T00:00:00-05:00</updated>
<author>
<name>Phyletica</name>
<uri>http://phyletica.org</uri>
<email>phyletica@auburn.edu</email>
</author>
<content type="html">
<h2 id="holden-moving-on-to-the-usgs">Holden moving on to the USGS</h2>
<p>Congratulations to undergraduate
Holden Smith
for accepting a position at the United States Geological Survey.
Holden will be working as a Hydrologic Technician out of he Lower Mississippi
Gulf Water Science Center in Tuscaloosa, Alabama.
He will be collecting important hydrologic data from extremely diverse
drainages, such as the Tennessee, Alabama, Tombigbee, and Mobile Rivers.
We will miss him in the lab, but we are glad to know he will be looking out for
the diverse waterways of the southeast.
Congrats Holden!</p>
<p><a href="http://phyletica.org/holden-usgs/">Holden joining the USGS</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on September 01, 2020.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Morgan joins the Phyleticians]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/welcome-morgan/" />
<id>http://phyletica.org/welcome-morgan</id>
<published>2020-08-23T00:00:00-05:00</published>
<updated>2020-08-23T00:00:00-05:00</updated>
<author>
<name>Phyletica</name>
<uri>http://phyletica.org</uri>
<email>phyletica@auburn.edu</email>
</author>
<content type="html">
<h2 id="welcome-morgan">Welcome Morgan!</h2>
<p>The Phyletical Lab is happy to welcome new Ph.D. student,
<a href="https://morganmuell.wixsite.com/home">Morgan Muell</a>.
Morgan joins us from the lab of
<a href="https://www.jasonleebrown.org/">Jason Brown</a>
at
<a href="https://siu.edu/">Southern Illinois University</a>,
where she did her master’s work on the phylogenomics and color pattern
evolution in poison frogs.
Morgan will be coadvised by
<a href="https://warnerlab.weebly.com/">Dan Warner</a>,
and is interested in taking a comparative approach to the evolution of
phenotypic plasticity.</p>
<p><a href="http://phyletica.org/welcome-morgan/">Morgan joins the Phyleticians</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on August 23, 2020.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Ryan heading to Villanova this Fall]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/ryan-villanova/" />
<id>http://phyletica.org/ryan-villanova</id>
<published>2020-07-11T00:00:00-05:00</published>
<updated>2020-07-11T00:00:00-05:00</updated>
<author>
<name>Phyletica</name>
<uri>http://phyletica.org</uri>
<email>phyletica@auburn.edu</email>
</author>
<content type="html">
<h2 id="ryan-is-philadelphia-bound">Ryan is Philadelphia bound</h2>
<p>Congratulations to
undergraduate
Ryan Cook
for being accepted into the graduate program at
<a href="https://www1.villanova.edu/university.html">Villanova University</a>.
Ryan will be working with
<a href="https://www1.villanova.edu/villanova/artsci/biology/facstaff.html?mail=aaron.bauer@villanova.edu&amp;xsl=bio">Aaron Bauer</a>
and
<a href="http://www87.homepage.villanova.edu/todd.jackman/">Todd Jackman</a>
on the diversification of reptiles and amphibians.</p>
<p><a href="http://phyletica.org/ryan-villanova/">Ryan heading to Villanova this Fall</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on July 11, 2020.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Paper: Insights from a general, full-likelihood Bayesian approach to inferring shared evolutionary events from genomic data]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/codemog-paper/" />
<id>http://phyletica.org/codemog-paper</id>
<published>2020-07-04T00:00:00-05:00</published>
<updated>2020-07-04T00:00:00-05:00</updated>
<author>
<name>Phyletica</name>
<uri>http://phyletica.org</uri>
<email>phyletica@auburn.edu</email>
</author>
<content type="html">
<p>While we avoid mass-infection events this 4th of July, here’s a
piece of good news out of the Phyletica Lab.
The work by
Nadia L’Bahy (our 2018 Comp Bio REU student from UMass Amherst)
and Kerry that introduces a new, full-likelihood, Bayesian approach
to estimating simultaneous changes in effective population sizes
across populations is now published in the journal
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/evo.14052">Evolution</a>.
It turns out that, even when you use all the information from genomic data,
estimating shared demographic events across populations is still super hard.</p>
<p><a href="http://phyletica.org/codemog-paper/">Paper: Insights from a general, full-likelihood Bayesian approach to inferring shared evolutionary events from genomic data</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on July 04, 2020.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Paper: Rivers of Indochina as potential drivers of diversification in flying lizards]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/draco-paper/" />
<id>http://phyletica.org/draco-paper</id>
<published>2020-06-10T00:00:00-05:00</published>
<updated>2020-06-10T00:00:00-05:00</updated>
<author>
<name>Phyletica</name>
<uri>http://phyletica.org</uri>
<email>phyletica@auburn.edu</email>
</author>
<content type="html">
<p><a href="http://randyklabacka.com/">Randy’s</a>
paper on the diversification of flying lizards across Indochina is now
<a href="https://doi.org/10.1016/j.ympev.2020.106861">published in Molecular Phylogenetics and Evolution</a>.
Randy found that a model of diversification demarcated by the major rivers of
Indochina best explained variation in sequence data from across the
distribution of the <em>Draco maculatus</em> species complex.
Randy did a ton of work to compare the marginal likelihoods of a large number
of diversification models to reach this conclusion.
Congrats Randy!</p>
<p><a href="http://phyletica.org/draco-paper/">Paper: Rivers of Indochina as potential drivers of diversification in flying lizards</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on June 10, 2020.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Randy gets AGA EECG award!]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/randy-aga-award/" />
<id>http://phyletica.org/randy-aga-award</id>
<published>2020-03-15T00:00:00-05:00</published>
<updated>2020-03-15T00:00:00-05:00</updated>
<author>
<name>Phyletica</name>
<uri>http://phyletica.org</uri>
<email>phyletica@auburn.edu</email>
</author>
<content type="html">
<h2 id="congrats-randy">Congrats Randy!</h2>
<p>Congratulations to
<a href="http://randyklabacka.com/">Randy Klabacka</a>
for being awarded $8,000 from the
<a href="https://www.theaga.org/eecg-awards.php">American Genetics Association</a>
to study the genomic and bioenergetic costs of asexuality
in whiptail lizards.
We are interested in whether a non-recombining nuclear genome can adequately
coevolve with the mitochondria.</p>
<p><a href="http://phyletica.org/randy-aga-award/">Randy gets AGA EECG award!</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on March 15, 2020.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Paper: The why, when, and how of computing in biology classrooms]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/comp-bio-ed/" />
<id>http://phyletica.org/comp-bio-ed</id>
<published>2020-03-05T00:00:00-06:00</published>
<updated>2020-03-05T00:00:00-06:00</updated>
<author>
<name>Phyletica</name>
<uri>http://phyletica.org</uri>
<email>phyletica@auburn.edu</email>
</author>
<content type="html">
<p>We have published an
<a href="https://f1000research.com/articles/8-1854/v2">opinion article about the ins-and-outs of
teaching computational biology</a>
in
<a href="https://f1000research.com/">F1000 Research</a>.
This work was born from a fantastic
<a href="https://www.ievobio.org/">iEvoBio</a> Meeting in Providence,
Rhode Island last Summer.
The meeting was organized by
<a href="https://paleantology.com/the-wright-lab/">April Wright</a>
and focused on “enabling the next generation of computational biologists”.
The paper was a lot of fun to work on, thanks to great collaborators
<a href="https://paleantology.com/the-wright-lab/">April Wright</a>,
<a href="https://schwartzlaburi.github.io/">Rachel Schwartz</a>,
<a href="https://www.catherinenewman.org/">Catherine Newman</a>,
and
<a href="https://www.canterbury.ac.nz/science/schools-and-departments/biological-sciences/contact-us/academic-staff/sarah-flanagan.html">Sarah Flanagan</a>.</p>
<p><a href="http://phyletica.org/comp-bio-ed/">Paper: The why, when, and how of computing in biology classrooms</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on March 05, 2020.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Paper: Comparative phylogeography of West African amphibians and reptiles]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/west-african-phylogeography/" />
<id>http://phyletica.org/west-african-phylogeography</id>
<published>2020-02-20T00:00:00-06:00</published>
<updated>2020-02-20T00:00:00-06:00</updated>
<author>
<name>Phyletica</name>
<uri>http://phyletica.org</uri>
<email>phyletica@auburn.edu</email>
</author>
<content type="html">
<p>Recent work in collaboration with
<a href="http://faculty.washington.edu/leache/wordpress/">Adam Leache</a>,
<a href="https://csir-forig.org.gh/senior-members-profiles/309-caleb-ofori-boateng-phd">Caleb Ofori-Boateng</a>,
and
<a href="https://fujitalab.com/">Matt Fujita</a>
is out in
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/evo.13941">Evolution</a>
on the comparative phylogeography of a diverse set of reptiles and amphibians
from West Africa.
We used computational methods developed in the Phyletica Lab to infer the
temporal distribution of divergences among 20 species across the Dahomey Gap.
We found a lot of variation in divergence times, suggesting that species
responded differently to past aridification across West Africa.</p>
<p><a href="http://phyletica.org/west-african-phylogeography/">Paper: Comparative phylogeography of West African amphibians and reptiles</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on February 20, 2020.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Charlotte gets Hyman Scholarship!]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/charlotte-hyman-award/" />
<id>http://phyletica.org/charlotte-hyman-award</id>
<published>2020-02-17T00:00:00-06:00</published>
<updated>2020-02-17T00:00:00-06:00</updated>
<author>
<name>Phyletica</name>
<uri>http://phyletica.org</uri>
<email>phyletica@auburn.edu</email>
</author>
<content type="html">
<h2 id="congrats-charlotte-again">Congrats Charlotte (again)!</h2>
<p>Congratulations to
undergraduate
Charlotte Benedict
for being awarded the
<a href="https://sicb.burkclients.com/grants/hyman/">Libbie H. Hyman Memorial Scholarship</a>
from the Societiy for Integrative and Comparative Biology.
This award provides Charlotte $3,000 to participate in the Marine
Invertebrate Zoology course at the University of Washington Friday Harbor Lab.
It’s been a good week for Charlotte!</p>
<p><a href="http://phyletica.org/charlotte-hyman-award/">Charlotte gets Hyman Scholarship!</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on February 17, 2020.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Charlotte gets graduate fellowship!]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/charlotte-osu-fellowship/" />
<id>http://phyletica.org/charlotte-osu-fellowship</id>
<published>2020-02-15T00:00:00-06:00</published>
<updated>2020-02-15T00:00:00-06:00</updated>
<author>
<name>Phyletica</name>
<uri>http://phyletica.org</uri>
<email>phyletica@auburn.edu</email>
</author>
<content type="html">
<h2 id="congrats-charlotte">Congrats Charlotte!</h2>
<p>Congratulations to
undergraduate
Charlotte Benedict
for being awarded a
<a href="https://gradsch.osu.edu/pursuing-your-degree/graduate-fellows/university-fellowship">University Fellowship from the Ohio State University</a>.
Charlotte will begin her graduate work at the OSU in the lab of
<a href="https://www.facebook.com/OSU-Lab-of-Marine-Invertebrate-Diversity-169688986441907/">Meg Daly</a>.</p>
<p><a href="http://phyletica.org/charlotte-osu-fellowship/">Charlotte gets graduate fellowship!</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on February 15, 2020.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Randy gets the Henri Seibert Award!]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/randy-seibert-award/" />
<id>http://phyletica.org/randy-seibert-award</id>
<published>2019-08-20T00:00:00-05:00</published>
<updated>2019-08-20T00:00:00-05:00</updated>
<author>
<name>Phyletica</name>
<uri>http://phyletica.org</uri>
<email>phyletica@auburn.edu</email>
</author>
<content type="html">
<h2 id="congrats-to-randy">Congrats to Randy!</h2>
<p>Congratulations to Randy Klabacka for
<a href="https://www.auburn.edu/cosam/news/articles/2019/08/auburn_student_honored_with_research_award_on_reptile_study.htm">winning the prestigious Henri Seibert Award</a>
at the
<a href="https://conferences.k-state.edu/jmih/">Joint Meeting of Ichthyologists and Herpetologists</a>.
This award from the
<a href="https://ssarherps.org/">Society for the Study of Amphibians and Reptiles</a>
recognizes the student with the best talk in one of four research categories.
Randy was awarded the best talk in Evolution/Systematics for his presentation
on “Riverine barriers as potential drivers of biodiversification in the <em>Draco
maculatus</em> species complex of Indochina.”
This project started out as a relatively simple exploration into this species
complex of gliding lizards.
However, Randy has done a great job transforming this work
into an in-depth comparison of
a large number of biogeographic models to determine the best explanation for
the current geographic distribution of this group’s genetic diversity across
Indochina.
Auburn University published
<a href="https://www.auburn.edu/cosam/news/articles/2019/08/auburn_student_honored_with_research_award_on_reptile_study.htm">a nice story</a>
about Randy’s accomplishment.</p>
<p><a href="http://phyletica.org/randy-seibert-award/">Randy gets the Henri Seibert Award!</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on August 20, 2019.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Claire and Tanner awarded AU fellowships]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/au-fellows/" />
<id>http://phyletica.org/au-fellows</id>
<published>2019-08-19T00:00:00-05:00</published>
<updated>2019-08-19T00:00:00-05:00</updated>
<author>
<name>Phyletica</name>
<uri>http://phyletica.org</uri>
<email>phyletica@auburn.edu</email>
</author>
<content type="html">
<h2 id="congrats-to-claire-and-tanner">Congrats to Claire and Tanner!</h2>
<p>New Phyletica Lab members, Claire Tracy and Tanner Myers, were awarded the
<a href="http://graduate.auburn.edu/au-presidential-graduate-research-fellowships/">Auburn University Presidential Graduate Research Fellowship</a>,
which includes three years of funding for their dissertation work.
Claire was also awarded the Allsup Fellowship for her first year at AU.
Congratulations, Claire and Tanner!</p>
<p><a href="http://phyletica.org/au-fellows/">Claire and Tanner awarded AU fellowships</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on August 19, 2019.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[The Phyletica Lab welcomes 4 new PhD students]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/new-grad-students/" />
<id>http://phyletica.org/new-grad-students</id>
<published>2019-08-15T00:00:00-05:00</published>
<updated>2019-08-15T00:00:00-05:00</updated>
<author>
<name>Phyletica</name>
<uri>http://phyletica.org</uri>
<email>phyletica@auburn.edu</email>
</author>
<content type="html">
<h2 id="welcome-tashitso-claire-matt-and-tanner">Welcome Tashitso, Claire, Matt, and Tanner!</h2>
<p>The Phyletica lab is welcoming four new Ph.D. students this week.
Tashitso Anamza joins us from Tibet, where she is from;
she also spent time in Lawrence, Kansas earning her bachelor’s and master’s
degrees from the University of Kansas.
Claire Tracy and Matt Buehler are joining us from
<a href="https://www1.villanova.edu">Villanova University</a>
where they are
finishing up their master’s work in
<a href="https://www1.villanova.edu/villanova/artsci/biology.html">Biology</a>.
Tanner Myers comes to us after finishing his B.Sc. at the University of Kansas
while working in the Herpetology Division of the
<a href="https://biodiversity.ku.edu/">KU Biodiversity Institute</a>.
Welcome, new phyleticians!</p>
<p><a href="http://phyletica.org/new-grad-students/">The Phyletica Lab welcomes 4 new PhD students</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on August 15, 2019.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Phyleticians in Providence for Evolution 2019]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/evolution-recap/" />
<id>http://phyletica.org/evolution-recap</id>
<published>2019-07-01T00:00:00-05:00</published>
<updated>2019-07-01T00:00:00-05:00</updated>
<author>
<name>Jamie Oaks</name>
<uri>http://phyletica.org</uri>
<email>joaks@auburn.edu</email>
</author>
<content type="html">
<p>Charlotte Benedict, Kerry Cobb, and I had a great time at
<a href="https://www.evolutionmeetings.org/evolution-2019---providence.html">Evolution 2019</a>
in Providence, RI.
Charlotte presented a great poster on the independent evolution of clownfish
symbiosis among sea anemones.
Kerry gave a poster about our work showing the difficulty of estimating
simultaneous demographic changes among populations
(see
<a href="/codemog-preprint/">post here</a>
and
<a href="https://www.biorxiv.org/content/10.1101/679878v1">preprint here</a>).
I talked about our
<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/evo.13754">recent paper</a>
on the comparative biogeography of Philippine geckos.
The slides from my talk are available for
<a href="/slides/evol2019.pdf">download here</a>
and can be viewed via
<a href="https://www.slideshare.net/jamieoaks7/full-bayesian-comparative-biogeography-of-philippine-geckos-challenges-predictions-of-climatedriven-vicariant-speciation">SlideShare</a>
here:</p>
<figure>
<iframe src="//www.slideshare.net/slideshow/embed_code/key/LPkpqnD9GjO2IA" width="595" height="485" frameborder="0" marginwidth="0" marginheight="0" scrolling="no" style="border:1px solid #CCC; border-width:1px; margin-bottom:5px; max-width: 100%;" allowfullscreen=""> </iframe>
<figcaption>
<p class="figure-caption-box">
<span class="center-if-single-line">
<strong> <a href="//www.slideshare.net/jamieoaks7/full-bayesian-comparative-biogeography-of-philippine-geckos-challenges-predictions-of-climatedriven-vicariant-speciation" title="Full Bayesian comparative biogeography of Philippine geckos challenges predictions of climate-driven vicariant speciation" target="_blank">Full Bayesian comparative biogeography of Philippine geckos challenges predictions of climate-driven vicariant speciation</a> </strong> from <strong><a href="https://www.slideshare.net/jamieoaks7" target="_blank">Jamie Oaks</a></strong>
</span>
</p>
</figcaption>
</figure>
<p>The recording of my talk is also
<a href="https://www.youtube.com/watch?v=gULtPGdAQME">up on YouTube</a>:</p>
<figure>
<iframe width="560" height="315" src="https://www.youtube.com/embed/gULtPGdAQME" frameborder="0" allow="accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture" allowfullscreen=""></iframe>
<figcaption>
<p class="figure-caption-box">
<span class="center-if-single-line">
Recording of Jamie's talk about the comparative biogeography of Philippine gekkonids.
</span>
</p>
</figcaption>
</figure>
<p>Kerry and I also attended the
<a href="https://ievobio2019.github.io/2019-iEvoBio/index.html">iEvoBio Conference</a>
the day after evolution, for
which I was a member of a panel on computational biology education.
The slides from my iEvoBio presentation can be
<a href="/slides/ievobio-2019">viewed here</a>.</p>
<p>We enjoyed our time in Providence and learned a ton from all the amazing talks
and posters we attended.
A huge thanks to the
<a href="https://www.amnat.org/home.html">ASN</a>,
<a href="https://www.systbio.org/">SSB</a>,
<a href="https://www.evolutionsociety.org/">SSE</a>,
and all the conference organizers for a wonderful event.</p>
<p><a href="http://phyletica.org/evolution-recap/">Phyleticians in Providence for Evolution 2019</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on July 01, 2019.</p>
</content>
</entry>
<entry>
<title type="html"><![CDATA[Preprint: Insights from a general, full-likelihood Bayesian approach to inferring shared evolutionary events from genomic data]]></title>
<link rel="alternate" type="text/html" href="http://phyletica.org/codemog-preprint/" />
<id>http://phyletica.org/codemog-preprint</id>
<published>2019-06-22T00:00:00-05:00</published>
<updated>2019-06-22T00:00:00-05:00</updated>
<author>
<name>Jamie Oaks</name>
<uri>http://phyletica.org</uri>
<email>joaks@auburn.edu</email>
</author>
<content type="html">
<p>A
<a href="https://www.biorxiv.org/content/10.1101/679878v1">new preprint</a>
out of the lab demostrates the difficulties in estimating simultaneous changes
in effective population sizes across taxa.
REU Nadia L’Bahy (our 2018 Comp Bio REU student from UMass Amherst) and Kerry
Cobb contributed to this work.
Feedback is welcome!</p>
<p><a href="http://phyletica.org/codemog-preprint/">Preprint: Insights from a general, full-likelihood Bayesian approach to inferring shared evolutionary events from genomic data</a> was originally published by Jamie Oaks at <a href="http://phyletica.org">phyletica</a> on June 22, 2019.</p>
</content>
</entry>
</feed>