diff --git a/llvm/lib/Transforms/Vectorize/VectorCombine.cpp b/llvm/lib/Transforms/Vectorize/VectorCombine.cpp
index 9239cb1b989b2..e581c225aec6f 100644
--- a/llvm/lib/Transforms/Vectorize/VectorCombine.cpp
+++ b/llvm/lib/Transforms/Vectorize/VectorCombine.cpp
@@ -2547,12 +2547,14 @@ bool VectorCombine::foldShuffleOfBinops(Instruction &I) {
 bool VectorCombine::foldShuffleOfSelects(Instruction &I) {
   ArrayRef<int> Mask;
   Value *C1, *T1, *F1, *C2, *T2, *F2;
-  if (!match(&I, m_Shuffle(
-                     m_OneUse(m_Select(m_Value(C1), m_Value(T1), m_Value(F1))),
-                     m_OneUse(m_Select(m_Value(C2), m_Value(T2), m_Value(F2))),
-                     m_Mask(Mask))))
+  if (!match(&I, m_Shuffle(m_Select(m_Value(C1), m_Value(T1), m_Value(F1)),
+                           m_Select(m_Value(C2), m_Value(T2), m_Value(F2)),
+                           m_Mask(Mask))))
     return false;
 
+  auto *Sel1 = cast<Instruction>(I.getOperand(0));
+  auto *Sel2 = cast<Instruction>(I.getOperand(1));
+
   auto *C1VecTy = dyn_cast<FixedVectorType>(C1->getType());
   auto *C2VecTy = dyn_cast<FixedVectorType>(C2->getType());
   if (!C1VecTy || !C2VecTy || C1VecTy != C2VecTy)
@@ -2570,11 +2572,14 @@ bool VectorCombine::foldShuffleOfSelects(Instruction &I) {
   auto *DstVecTy = cast<FixedVectorType>(I.getType());
   auto SK = TargetTransformInfo::SK_PermuteTwoSrc;
   auto SelOp = Instruction::Select;
-  InstructionCost OldCost = TTI.getCmpSelInstrCost(
+
+  InstructionCost CostSel1 = TTI.getCmpSelInstrCost(
       SelOp, SrcVecTy, C1VecTy, CmpInst::BAD_ICMP_PREDICATE, CostKind);
-  OldCost += TTI.getCmpSelInstrCost(SelOp, SrcVecTy, C2VecTy,
-                                    CmpInst::BAD_ICMP_PREDICATE, CostKind);
-  OldCost +=
+  InstructionCost CostSel2 = TTI.getCmpSelInstrCost(
+      SelOp, SrcVecTy, C2VecTy, CmpInst::BAD_ICMP_PREDICATE, CostKind);
+
+  InstructionCost OldCost =
+      CostSel1 + CostSel2 +
       TTI.getShuffleCost(SK, DstVecTy, SrcVecTy, Mask, CostKind, 0, nullptr,
                          {I.getOperand(0), I.getOperand(1)}, &I);
 
@@ -2590,6 +2595,11 @@ bool VectorCombine::foldShuffleOfSelects(Instruction &I) {
   NewCost += TTI.getCmpSelInstrCost(SelOp, DstVecTy, C1C2ShuffledVecTy,
                                     CmpInst::BAD_ICMP_PREDICATE, CostKind);
 
+  if (!Sel1->hasOneUse())
+    NewCost += CostSel1;
+  if (!Sel2->hasOneUse())
+    NewCost += CostSel2;
+
   LLVM_DEBUG(dbgs() << "Found a shuffle feeding two selects: " << I
                     << "\n  OldCost: " << OldCost << " vs NewCost: " << NewCost
                     << "\n");
diff --git a/llvm/test/Transforms/VectorCombine/X86/shuffle-of-selects.ll b/llvm/test/Transforms/VectorCombine/X86/shuffle-of-selects.ll
index 7883eb42aefac..cf57a503c2197 100644
--- a/llvm/test/Transforms/VectorCombine/X86/shuffle-of-selects.ll
+++ b/llvm/test/Transforms/VectorCombine/X86/shuffle-of-selects.ll
@@ -637,3 +637,87 @@ define <4 x i32> @src_v2tov4_i32_change_to_other_vector(<2 x i1> %a, <2 x i1> %b
   %res = shufflevector <2 x i32> %select.xz, <2 x i32> %select.yx, <4 x i32> <i32 2, i32 3, i32 0, i32 1>
   ret <4 x i32> %res
 }
+
+define <4 x i32> @src_v2tov4_i32_multiuse_sel1(<2 x i1> %a, <2 x i1> %b, <2 x i32> %x, <2 x i32> %y, <2 x i32> %z, ptr %p) {
+; CHECK-LABEL: define <4 x i32> @src_v2tov4_i32_multiuse_sel1(
+; CHECK-SAME: <2 x i1> [[A:%.*]], <2 x i1> [[B:%.*]], <2 x i32> [[X:%.*]], <2 x i32> [[Y:%.*]], <2 x i32> [[Z:%.*]], ptr [[P:%.*]]) #[[ATTR0]] {
+; CHECK-NEXT:    [[SELECT_XZ:%.*]] = select <2 x i1> [[A]], <2 x i32> [[X]], <2 x i32> [[Z]]
+; CHECK-NEXT:    store <2 x i32> [[SELECT_XZ]], ptr [[P]], align 8
+; CHECK-NEXT:    [[SELECT_YX:%.*]] = select <2 x i1> [[B]], <2 x i32> [[Y]], <2 x i32> [[X]]
+; CHECK-NEXT:    [[RES:%.*]] = shufflevector <2 x i32> [[SELECT_XZ]], <2 x i32> [[SELECT_YX]], <4 x i32> <i32 0, i32 1, i32 2, i32 3>
+; CHECK-NEXT:    ret <4 x i32> [[RES]]
+;
+  %select.xz = select <2 x i1> %a, <2 x i32> %x, <2 x i32> %z
+  store <2 x i32> %select.xz, ptr %p
+  %select.yx = select <2 x i1> %b, <2 x i32> %y, <2 x i32> %x
+  %res = shufflevector <2 x i32> %select.xz, <2 x i32> %select.yx, <4 x i32> <i32 0, i32 1, i32 2, i32 3>
+  ret <4 x i32> %res
+}
+
+define <4 x i32> @src_v2tov4_i32_multiuse_sel2(<2 x i1> %a, <2 x i1> %b, <2 x i32> %x, <2 x i32> %y, <2 x i32> %z, ptr %p) {
+; CHECK-LABEL: define <4 x i32> @src_v2tov4_i32_multiuse_sel2(
+; CHECK-SAME: <2 x i1> [[A:%.*]], <2 x i1> [[B:%.*]], <2 x i32> [[X:%.*]], <2 x i32> [[Y:%.*]], <2 x i32> [[Z:%.*]], ptr [[P:%.*]]) #[[ATTR0]] {
+; CHECK-NEXT:    [[SELECT_XZ:%.*]] = select <2 x i1> [[A]], <2 x i32> [[X]], <2 x i32> [[Z]]
+; CHECK-NEXT:    [[SELECT_YX:%.*]] = select <2 x i1> [[B]], <2 x i32> [[Y]], <2 x i32> [[X]]
+; CHECK-NEXT:    store <2 x i32> [[SELECT_YX]], ptr [[P]], align 8
+; CHECK-NEXT:    [[RES:%.*]] = shufflevector <2 x i32> [[SELECT_XZ]], <2 x i32> [[SELECT_YX]], <4 x i32> <i32 0, i32 1, i32 2, i32 3>
+; CHECK-NEXT:    ret <4 x i32> [[RES]]
+;
+  %select.xz = select <2 x i1> %a, <2 x i32> %x, <2 x i32> %z
+  %select.yx = select <2 x i1> %b, <2 x i32> %y, <2 x i32> %x
+  store <2 x i32> %select.yx, ptr %p
+  %res = shufflevector <2 x i32> %select.xz, <2 x i32> %select.yx, <4 x i32> <i32 0, i32 1, i32 2, i32 3>
+  ret <4 x i32> %res
+}
+
+define <4 x i32> @src_v2tov4_i32_multiuse_both(<2 x i1> %a, <2 x i1> %b, <2 x i32> %x, <2 x i32> %y, <2 x i32> %z, ptr %p1, ptr %p2) {
+; CHECK-LABEL: define <4 x i32> @src_v2tov4_i32_multiuse_both(
+; CHECK-SAME: <2 x i1> [[A:%.*]], <2 x i1> [[B:%.*]], <2 x i32> [[X:%.*]], <2 x i32> [[Y:%.*]], <2 x i32> [[Z:%.*]], ptr [[P1:%.*]], ptr [[P2:%.*]]) #[[ATTR0]] {
+; CHECK-NEXT:    [[SELECT_XZ:%.*]] = select <2 x i1> [[A]], <2 x i32> [[X]], <2 x i32> [[Z]]
+; CHECK-NEXT:    store <2 x i32> [[SELECT_XZ]], ptr [[P1]], align 8
+; CHECK-NEXT:    [[SELECT_YX:%.*]] = select <2 x i1> [[B]], <2 x i32> [[Y]], <2 x i32> [[X]]
+; CHECK-NEXT:    store <2 x i32> [[SELECT_YX]], ptr [[P2]], align 8
+; CHECK-NEXT:    [[RES:%.*]] = shufflevector <2 x i32> [[SELECT_XZ]], <2 x i32> [[SELECT_YX]], <4 x i32> <i32 0, i32 1, i32 2, i32 3>
+; CHECK-NEXT:    ret <4 x i32> [[RES]]
+;
+  %select.xz = select <2 x i1> %a, <2 x i32> %x, <2 x i32> %z
+  store <2 x i32> %select.xz, ptr %p1
+  %select.yx = select <2 x i1> %b, <2 x i32> %y, <2 x i32> %x
+  store <2 x i32> %select.yx, ptr %p2
+  %res = shufflevector <2 x i32> %select.xz, <2 x i32> %select.yx, <4 x i32> <i32 0, i32 1, i32 2, i32 3>
+  ret <4 x i32> %res
+}
+
+define <2 x i32> @src_v1024tov2_i32_multiuse_sel1(<1024 x i1> %a, <1024 x i1> %b, <1024 x i32> %x, <1024 x i32> %y, <1024 x i32> %z, ptr %p1, ptr %p2) {
+; SSE-LABEL: define <2 x i32> @src_v1024tov2_i32_multiuse_sel1(
+; SSE-SAME: <1024 x i1> [[A:%.*]], <1024 x i1> [[B:%.*]], <1024 x i32> [[X:%.*]], <1024 x i32> [[Y:%.*]], <1024 x i32> [[Z:%.*]], ptr [[P1:%.*]], ptr [[P2:%.*]]) #[[ATTR0]] {
+; SSE-NEXT:    [[SELECT_XZ:%.*]] = select <1024 x i1> [[A]], <1024 x i32> [[X]], <1024 x i32> [[Z]]
+; SSE-NEXT:    store <1024 x i32> [[SELECT_XZ]], ptr [[P1]], align 4096
+; SSE-NEXT:    [[SELECT_YX:%.*]] = select <1024 x i1> [[B]], <1024 x i32> [[Y]], <1024 x i32> [[X]]
+; SSE-NEXT:    [[RES:%.*]] = shufflevector <1024 x i32> [[SELECT_XZ]], <1024 x i32> [[SELECT_YX]], <2 x i32> <i32 0, i32 1024>
+; SSE-NEXT:    ret <2 x i32> [[RES]]
+;
+; AVX2-LABEL: define <2 x i32> @src_v1024tov2_i32_multiuse_sel1(
+; AVX2-SAME: <1024 x i1> [[A:%.*]], <1024 x i1> [[B:%.*]], <1024 x i32> [[X:%.*]], <1024 x i32> [[Y:%.*]], <1024 x i32> [[Z:%.*]], ptr [[P1:%.*]], ptr [[P2:%.*]]) #[[ATTR0]] {
+; AVX2-NEXT:    [[SELECT_XZ:%.*]] = select <1024 x i1> [[A]], <1024 x i32> [[X]], <1024 x i32> [[Z]]
+; AVX2-NEXT:    store <1024 x i32> [[SELECT_XZ]], ptr [[P1]], align 4096
+; AVX2-NEXT:    [[SELECT_YX:%.*]] = select <1024 x i1> [[B]], <1024 x i32> [[Y]], <1024 x i32> [[X]]
+; AVX2-NEXT:    [[RES:%.*]] = shufflevector <1024 x i32> [[SELECT_XZ]], <1024 x i32> [[SELECT_YX]], <2 x i32> <i32 0, i32 1024>
+; AVX2-NEXT:    ret <2 x i32> [[RES]]
+;
+; AVX512-LABEL: define <2 x i32> @src_v1024tov2_i32_multiuse_sel1(
+; AVX512-SAME: <1024 x i1> [[A:%.*]], <1024 x i1> [[B:%.*]], <1024 x i32> [[X:%.*]], <1024 x i32> [[Y:%.*]], <1024 x i32> [[Z:%.*]], ptr [[P1:%.*]], ptr [[P2:%.*]]) #[[ATTR0]] {
+; AVX512-NEXT:    [[SELECT_XZ:%.*]] = select <1024 x i1> [[A]], <1024 x i32> [[X]], <1024 x i32> [[Z]]
+; AVX512-NEXT:    store <1024 x i32> [[SELECT_XZ]], ptr [[P1]], align 4096
+; AVX512-NEXT:    [[TMP1:%.*]] = shufflevector <1024 x i1> [[A]], <1024 x i1> [[B]], <2 x i32> <i32 0, i32 1024>
+; AVX512-NEXT:    [[TMP2:%.*]] = shufflevector <1024 x i32> [[X]], <1024 x i32> [[Y]], <2 x i32> <i32 0, i32 1024>
+; AVX512-NEXT:    [[TMP3:%.*]] = shufflevector <1024 x i32> [[Z]], <1024 x i32> [[X]], <2 x i32> <i32 0, i32 1024>
+; AVX512-NEXT:    [[RES:%.*]] = select <2 x i1> [[TMP1]], <2 x i32> [[TMP2]], <2 x i32> [[TMP3]]
+; AVX512-NEXT:    ret <2 x i32> [[RES]]
+;
+  %select.xz = select <1024 x i1> %a, <1024 x i32> %x, <1024 x i32> %z
+  store <1024 x i32> %select.xz, ptr %p1
+  %select.yx = select <1024 x i1> %b, <1024 x i32> %y, <1024 x i32> %x
+  %res = shufflevector <1024 x i32> %select.xz, <1024 x i32> %select.yx, <2 x i32> <i32 0, i32 1024>
+  ret <2 x i32> %res
+}