diff --git a/01-intro2Genomics.Rmd b/01-intro2Genomics.Rmd index 88bd829..1b04543 100644 --- a/01-intro2Genomics.Rmd +++ b/01-intro2Genomics.Rmd @@ -345,7 +345,7 @@ restricted to CpG dinucleotides, methylation can occur in other bases as well). binding on the region, or methyl-CpG binding proteins induce the spread of repressive chromatin domains, thus the gene is silenced if its promoter has methylated CG dinucleotides. DNA methylation usually occurs in repeat -sequences to repress transposable elements. These elements, when active, can +sequences to repress transposable elements (Suggestion: DNA methylation usually occurs in repeat sequences, especially in transposable elements, to keep them inactive/repressed). These elements, when active, can jump around and insert them to random parts of the genome, potentially disrupting the genomic functions.\index{CpG island} @@ -830,3 +830,5 @@ Consortium | What is it for? \index{ENCODE} \index{Epigenomics Roadmap} \index{The Cancer Genome Atlas (TCGA)} + +