diff --git a/megatron/core/transformer/moe/fused_a2a.py b/megatron/core/transformer/moe/fused_a2a.py
index 586d70c400f..91a3bf0cffb 100644
--- a/megatron/core/transformer/moe/fused_a2a.py
+++ b/megatron/core/transformer/moe/fused_a2a.py
@@ -3,6 +3,7 @@
 # Copyright (c) 2025 DeepSeek
 # Licensed under the MIT License - https://github.com/deepseek-ai/DeepEP/blob/main/LICENSE
 
+import os
 from typing import Optional
 
 from megatron.core.utils import internal_api
@@ -268,6 +269,7 @@ def set_deepep_num_sms(num_sms):
 
 
 try:
+    import hybrid_ep_cpp
     from deep_ep import HybridEPBuffer
 
     HAVE_HYBRIDEP = True
@@ -275,12 +277,68 @@ def set_deepep_num_sms(num_sms):
     HAVE_HYBRIDEP = False
 
 _hybrid_ep_buffer = None
+_HYBRID_EP_TOKEN_ALIGNMENT = 16
+_HYBRID_EP_MIN_BUFFER_TOKENS = 512
+_HYBRID_EP_IB_QP_MAX_DEPTH = 65535
+_HYBRID_EP_IB_DISPATCH_DEPTH_PER_TOKEN = 3
+
+
+def _round_up_to_multiple(value: int, multiple: int) -> int:
+    return ((value + multiple - 1) // multiple) * multiple
+
+
+def _hybrid_ep_num_nodes(group: torch.distributed.ProcessGroup) -> int:
+    """Mirror HybridEP's NVLink-domain detection without constructing the full buffer."""
+    ranks_per_nvlink_domain_env = os.getenv("NUM_OF_HYBRID_EP_RANKS_PER_NVLINK_DOMAIN")
+    if ranks_per_nvlink_domain_env is not None:
+        ranks_per_nvlink_domain = int(ranks_per_nvlink_domain_env)
+    else:
+        allocator = hybrid_ep_cpp.ExtendedMemoryAllocator()
+        ranks_per_nvlink_domain = allocator.detect_accessible_ranks(group)
+
+    assert group.size() % ranks_per_nvlink_domain == 0, (
+        f"The number of ranks {group.size()} should be divisible by the number of ranks per "
+        f"NVLink domain {ranks_per_nvlink_domain}."
+    )
+    return group.size() // ranks_per_nvlink_domain
+
+
+def _hybrid_ep_uses_internode_rdma(group: torch.distributed.ProcessGroup) -> bool:
+    if _hybrid_ep_buffer is not None and hasattr(_hybrid_ep_buffer, "num_of_nodes"):
+        return _hybrid_ep_buffer.num_of_nodes > 1
+    return _hybrid_ep_num_nodes(group) > 1
+
+
+def _validate_hybrid_ep_ib_tx_depth(num_tokens: int, group: torch.distributed.ProcessGroup) -> None:
+    buffer_tokens = max(
+        _round_up_to_multiple(num_tokens, _HYBRID_EP_TOKEN_ALIGNMENT), _HYBRID_EP_MIN_BUFFER_TOKENS
+    )
+    tx_depth = _HYBRID_EP_IB_DISPATCH_DEPTH_PER_TOKEN * buffer_tokens + 1
+    if tx_depth <= _HYBRID_EP_IB_QP_MAX_DEPTH:
+        return
+
+    if not _hybrid_ep_uses_internode_rdma(group):
+        return
+
+    max_supported_tokens = (
+        ((_HYBRID_EP_IB_QP_MAX_DEPTH - 1) // _HYBRID_EP_IB_DISPATCH_DEPTH_PER_TOKEN)
+        // _HYBRID_EP_TOKEN_ALIGNMENT
+        * _HYBRID_EP_TOKEN_ALIGNMENT
+    )
+    raise ValueError(
+        f"HybridEP InfiniBand dispatch queue pair depth ({tx_depth}) exceeds the hardware "
+        f"limit of {_HYBRID_EP_IB_QP_MAX_DEPTH}. DeepEP computes this depth from the "
+        f"tokens per rank rounded up to a {_HYBRID_EP_TOKEN_ALIGNMENT}-token buffer "
+        f"alignment ({buffer_tokens}). Reduce sequence length or micro-batch size, or "
+        f"increase Tensor Parallelism (TP) / Context Parallelism (CP), so tokens per rank "
+        f"are at most {max_supported_tokens} for multi-node HybridEP."
+    )
 
 
 def init_hybrid_ep_buffer(
     group: torch.distributed.ProcessGroup,
     hidden_dim: int,
-    seq_len: int,
+    num_tokens: int,
     num_local_experts: int,
     num_sms_dispatch_api: Optional[int] = None,
     num_sms_combine_api: Optional[int] = None,
@@ -301,8 +359,8 @@ def init_hybrid_ep_buffer(
             Process group for HybridEP all-to-all communication.
         hidden_dim (int):
             Hidden dimension of the input tensor.
-        seq_len (int):
-            Maximum sequence length of the input tensor.
+        num_tokens (int):
+            Maximum token count of the input tensor.
         num_local_experts (int):
             Number of local experts.
         num_sms_dispatch_api (Optional[int]):
@@ -330,7 +388,7 @@ def init_hybrid_ep_buffer(
     _hybrid_ep_buffer = HybridEPBuffer(
         group=group,
         hidden_dim=hidden_dim,
-        max_num_of_tokens_per_rank=seq_len,
+        max_num_of_tokens_per_rank=num_tokens,
         num_local_experts=num_local_experts,
         use_fp8=fp8_dispatch,
         **kwargs,
@@ -386,13 +444,14 @@ def forward(
                 num_blocks_permute = None
                 num_blocks_unpermute = None
 
+        num_tokens, hidden_dim = x.shape[-2:]
+        _validate_hybrid_ep_ib_tx_depth(num_tokens, group)
         if _hybrid_ep_buffer is None:
-            seq_len, hidden_dim = x.shape[-2:]
             fp8_dispatch = False  # Currently, we do not support fp8 dispatch
             init_hybrid_ep_buffer(
                 group,
                 hidden_dim,
-                seq_len,
+                num_tokens,
                 num_local_experts,
                 num_sms_dispatch_api,
                 num_sms_combine_api,