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docs: reorganize ClawBio tutorials into sequential 5-step workshop flow
Reorder tutorials for the Segun workshop (22 April): Run Skill → Build
Skill → Variant Interpretation → GWAS → 30x WGS. Add missing GWAS card
to index. Move Telegram Bot to bonus. Add step numbering to nav sidebar
and breadcrumb navigation to every tutorial page.
Co-Authored-By: Claude Opus 4.6 (1M context) <noreply@anthropic.com>
Copy file name to clipboardExpand all lines: docs/tutorials/30x-wgs-workshop.md
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@@ -18,8 +18,8 @@ description: Explore a real 30x whole-genome sequence with ClawBio in Google Col
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!!! warning "Early release: testers welcome"
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This workshop has not been fully tested end-to-end. If you hit errors, please [file an issue on GitHub](https://github.com/ClawBio/ClawBio/issues) or message Manuel directly. Your feedback makes this better for everyone.
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!!! tip "Builds on Workshops 1 and 2"
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This is the third and final workshop in the series. In the [Variant Interpretation Workshop](variant-interpretation-workshop.md) you analysed a SNP array (~600K positions). In the [GWAS Workshop](gwas-workshop.md) you scaled up to population-level analysis. Now you return to the same individual genome at **full 30x whole-genome sequencing resolution**, revealing variant types that are invisible to both arrays and summary statistics.
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!!! tip "Step 5 of 5: Builds on Steps 3 and 4"
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This is the final step in the ClawBio tutorial sequence. In **Step 3** ([Variant Interpretation Workshop](variant-interpretation-workshop.md)) you analysed a SNP array (~600K positions). In **Step 4** ([GWAS Workshop](gwas-workshop.md)) you scaled up to population-level analysis. Now you return to the same individual genome at **full 30x whole-genome sequencing resolution**, revealing variant types that are invisible to both arrays and summary statistics.
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## What's new compared to previous workshops
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---
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**Next:**[Variant Interpretation Workshop](variant-interpretation-workshop.md) — analyse a real genome hands-on.
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**Previous:**[Run Your First Skill](run-your-first-skill.md) | **Next step:**[Variant Interpretation Workshop](variant-interpretation-workshop.md) — analyse a real genome hands-on.
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**Full workshop sequence:**[Run Your First Skill](run-your-first-skill.md) :material-arrow-right: Build a Skill :material-arrow-right: [Variant Interpretation](variant-interpretation-workshop.md) :material-arrow-right: [GWAS](gwas-workshop.md) :material-arrow-right: [30x WGS](30x-wgs-workshop.md)
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!!! tip "Runs in Google Colab"
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All code in this workshop runs in Google Colab. Open a new notebook, clone ClawBio (`!git clone https://github.com/ClawBio/ClawBio.git` then `%cd ClawBio` and `!pip install -q -r requirements.txt`), and follow along.
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!!! tip "Builds on the Variant Interpretation Workshop"
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This is the second workshop in the series. In the [Variant Interpretation Workshop](variant-interpretation-workshop.md) you annotated a **single genome** and found clinically relevant variants. Now we scale up: from one person to **population-level** analysis using GWAS summary statistics. You will query the same variant (rs429358/APOE) you found before, but this time across thousands of genomes and nine databases.
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!!! tip "Step 4 of 5: Builds on the Variant Interpretation Workshop"
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This is **Step 4**in the ClawBio tutorial sequence. In **Step 3** ([Variant Interpretation Workshop](variant-interpretation-workshop.md)) you annotated a **single genome** and found clinically relevant variants. Now we scale up: from one person to **population-level** analysis using GWAS summary statistics. You will query the same variant (rs429358/APOE) you found before, but this time across thousands of genomes and nine databases.
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---
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| Workshop | What it adds |
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|----------|-------------|
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|[30x WGS Workshop](30x-wgs-workshop.md)| Analyse Manuel Corpas's genome at **full 30x whole-genome sequencing resolution**. Discover 8,925 structural variants, 912K indels, and copy number changes that are invisible to both SNP arrays and summary statistics. Compare WGS findings with the SNP chip results from Workshop 1. |
<pclass="tutorial-card__desc">Annotate a real human genome in Google Colab. Variant annotation, pharmacogenomics, and clinical interpretation. No prior experience required.</p>
<pclass="tutorial-card__desc">Annotate a real human genome in Google Colab. No installation, no terminal, no prior experience required. Covers variant annotation, pharmacogenomics, and clinical interpretation.</p>
<pclass="tutorial-card__desc">Scale from one genome to population-level analysis. GWAS variant lookup across 9 databases, polygenic risk scores, and SuSiE fine-mapping.</p>
<pclass="tutorial-card__desc">Explore a real 30x whole-genome sequence in Google Colab. Structural variants, QC metrics, pharmacogenomics comparison. Goes beyond what SNP arrays can see.</p>
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<pclass="tutorial-card__desc">Explore a real 30x whole-genome sequence. Structural variants, QC metrics, and pharmacogenomics comparison. Goes beyond what SNP arrays can see.</p>
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---
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**Next:**[Build a Skill](build-a-skill.md) — create your own skill from scratch.
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**Next step:**[Build a Skill](build-a-skill.md) — create your own skill from scratch.
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**Full workshop sequence:** Run Your First Skill :material-arrow-right: [Build a Skill](build-a-skill.md) :material-arrow-right: [Variant Interpretation](variant-interpretation-workshop.md) :material-arrow-right: [GWAS](gwas-workshop.md) :material-arrow-right: [30x WGS](30x-wgs-workshop.md)
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[:material-open-in-new: Launch the workshop in Google Colab](https://colab.research.google.com/github/ClawBio/ClawBio/blob/main/docs/tutorial-variant-interpretation.ipynb){ .md-button .md-button--primary }
!!! tip "Step 3 of 5: Your first hands-on genomics workshop"
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This is **Step 3** in the ClawBio tutorial sequence. In [Step 1](run-your-first-skill.md) you ran a skill demo. In [Step 2](build-a-skill.md) you built a skill from scratch. Now you apply ClawBio to a real human genome: variant annotation, pharmacogenomics, and clinical interpretation.
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## Part 1: What is ClawBio?
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|----------|-------------|-------|
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|[GWAS Workshop](gwas-workshop.md)| Scale from one genome to **population-level** analysis. Query nine GWAS databases, compute polygenic risk scores, and fine-map causal variants using public summary statistics. | Intermediate |
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|[30x WGS Workshop](30x-wgs-workshop.md)| Analyse the **same genome at full resolution** (30x whole-genome sequencing). Discover structural variants, indels, and copy number changes invisible to SNP arrays. | Intermediate |
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**Previous:**[Build a Skill](build-a-skill.md) | **Next step:**[GWAS Workshop](gwas-workshop.md)
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**Full workshop sequence:**[Run Your First Skill](run-your-first-skill.md) :material-arrow-right: [Build a Skill](build-a-skill.md) :material-arrow-right: Variant Interpretation :material-arrow-right: [GWAS](gwas-workshop.md) :material-arrow-right: [30x WGS](30x-wgs-workshop.md)
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