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<!DOCTYPE html>
<html lang="en">
<head>
<meta charset="UTF-8">
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<title>🦖 ClawBio — Bioinformatics AI Agent Skills</title>
<meta name="description" content="ClawBio is the first bioinformatics-native AI agent skill library. Run GWAS, phylogenetics, proteomics and more — local-first, privacy-focused, and fully reproducible. Built on OpenClaw.">
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<meta property="og:description" content="ClawBio is the first bioinformatics-native AI agent skill library. Run GWAS, phylogenetics, proteomics and more — local-first, privacy-focused, and fully reproducible. Built on OpenClaw.">
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<meta name="twitter:description" content="ClawBio is the first bioinformatics-native AI agent skill library. Run GWAS, phylogenetics, proteomics and more — local-first, privacy-focused, and fully reproducible. Built on OpenClaw.">
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</head>
<body>
<nav>
<a class="nav-logo" href="#"><span>🦖</span> ClawBio</a>
<ul class="nav-links">
<li><a href="#skills">Skills</a></li>
<li><a href="#why">Why ClawBio</a></li>
<li><a href="#showcase">Showcase</a></li>
<li><a href="#community">Community</a></li>
<li><a href="https://github.com/ClawBio/ClawBio" target="_blank">GitHub</a></li>
</ul>
</nav>
<section class="hero">
<div class="hero-badge">Now live — presented at London Bioinformatics Meetup, Feb 2026</div>
<h1>The first <em>bioinformatics-native</em><br>AI agent skill library</h1>
<p>Every figure in your paper should be one command away from reproduction. Local-first. Privacy-focused. Reproducible. Built on OpenClaw.</p>
<div class="hero-ctas">
<a class="btn btn-primary" href="https://github.com/ClawBio/ClawBio" target="_blank">⭐ View on GitHub</a>
<a class="btn btn-secondary" href="https://github.com/ClawBio/ClawBio/blob/main/CONTRIBUTING.md" target="_blank">Submit a Skill</a>
</div>
<div class="hero-pills">
<span class="pill">bioinformatics</span><span class="pill">genomics</span><span class="pill">reproducibility</span><span class="pill">population-genetics</span><span class="pill">equity</span><span class="pill">ai-agents</span><span class="pill">local-first</span><span class="pill">openclaw</span>
</div>
</section>
<section style="padding:3rem 2rem;text-align:center;">
<div style="max-width:800px;margin:0 auto;">
<video controls preload="metadata" style="width:100%;border-radius:10px;border:1px solid var(--border);" poster="https://raw.githubusercontent.com/ClawBio/ClawBio/main/img/clawbio-social-preview.png">
<source src="https://github.com/ClawBio/ClawBio/releases/download/v0.2.0/david-nutrigx-demo.mp4" type="video/mp4">
</video>
<p style="color:var(--text-muted);font-size:0.85rem;margin-top:0.75rem;">NutriGx Advisor — community-contributed skill running locally on raw genetic data</p>
</div>
</section>
<section class="problem-bg">
<div class="section-inner">
<div class="section-label">The Problem</div>
<div class="section-title">Reproducing bioinformatics analyses is broken</div>
<div class="problem-grid">
<div>
<div class="code-block">
<div class="comment"># Without ClawBio</div>
<div class="error">$ git clone repo && cd repo</div>
<div class="error"># Wrong Python version...</div>
<div class="error"># Reference data link is dead...</div>
<div class="error"># Paths hardcoded to /home/jsmith/data/</div>
<div class="error"># Email first author. Wait 3 weeks.</div>
<div class="error"># Give up.</div>
</div>
<ul class="pain-list">
<li><span class="x">✗</span> Dependency hell & broken environments</li>
<li><span class="x">✗</span> Dead links to reference data</li>
<li><span class="x">✗</span> Hardcoded paths & missing configs</li>
<li><span class="x">✗</span> AI hallucinates star alleles & outdated guidelines</li>
<li><span class="x">✗</span> No audit trail, no checksums</li>
</ul>
</div>
<div>
<div class="code-block">
<div class="comment"># With ClawBio</div>
<div class="cmd">$ python ancestry_pca.py --demo --output fig3</div>
<br>
<div class="success">✓ Figure 3 reproduced.</div>
<div class="success">✓ Identical. SHA-256 verified.</div>
<div class="success">✓ 30 seconds.</div>
<br>
<div class="comment"># Or with natural language:</div>
<div class="cmd">$ openclaw "Profile my pharmacogenes"</div>
</div>
<p style="color:var(--text-muted);font-size:0.9rem;margin-top:1rem;">Every skill exports <code style="background:var(--bg3);padding:0.1rem 0.4rem;border-radius:4px;font-size:0.85rem;">commands.sh</code>, <code style="background:var(--bg3);padding:0.1rem 0.4rem;border-radius:4px;font-size:0.85rem;">environment.yml</code>, and SHA-256 checksums — anyone can reproduce without the agent.</p>
</div>
</div>
</div>
</section>
<section id="why">
<div class="section-inner">
<div class="section-label">Why ClawBio</div>
<div class="section-title">Domain expertise, frozen into code</div>
<p class="section-sub">ChatGPT and Claude are smart generalists. ClawBio skills are domain experts' proven pipelines — executed correctly every time.</p>
<div class="features-grid">
<div class="feature-card"><div class="feature-icon">🏠</div><div class="feature-title">Local-first</div><div class="feature-desc">Your genomic data never leaves your laptop. No cloud uploads, no data exfiltration. Full privacy by design.</div></div>
<div class="feature-card"><div class="feature-icon">🔁</div><div class="feature-title">Reproducible</div><div class="feature-desc">Every analysis exports a reproducibility bundle — commands, environment, and SHA-256 checksums. Reproduce without the agent.</div></div>
<div class="feature-card"><div class="feature-icon">🧩</div><div class="feature-title">Modular</div><div class="feature-desc">Each skill is a self-contained directory (SKILL.md + Python scripts) that plugs into the orchestrator — or runs standalone.</div></div>
<div class="feature-card"><div class="feature-icon">⚖️</div><div class="feature-title">MIT Licensed</div><div class="feature-desc">Open-source, free, community-driven. Clone it, run it, build a skill, submit a PR.</div></div>
<div class="feature-card"><div class="feature-icon">🌍</div><div class="feature-title">Equity-aware</div><div class="feature-desc">Built-in support for underrepresented populations. HEIM diversity metrics baked into the roadmap.</div></div>
<div class="feature-card"><div class="feature-icon">🦞</div><div class="feature-title">Built on OpenClaw</div><div class="feature-desc">Powered by OpenClaw (180k+ GitHub stars) — the agent platform that routes natural language to the right specialist skill.</div></div>
</div>
</div>
</section>
<section id="skills" style="background:var(--bg2);border-top:1px solid var(--border);border-bottom:1px solid var(--border);">
<div class="section-inner">
<div class="section-label">Skills Library</div>
<div class="section-title">8 skills — live now</div>
<p class="section-sub">Each skill includes demo data so you can try it immediately without your own files.</p>
<div class="skills-grid">
<div class="skill-card"><div><div class="skill-name">🧭 Bio Orchestrator</div><div class="skill-desc">Routes bioinformatics requests to the right specialist skill by file type and keywords.</div></div><span class="skill-badge badge-mvp">MVP</span></div>
<div class="skill-card"><div><div class="skill-name">💊 PharmGx Reporter</div><div class="skill-desc">Pharmacogenomic report from 23andMe/AncestryDNA: 12 genes, 51 drugs, CPIC guidelines. Runs in <1 second.</div></div><span class="skill-badge badge-mvp">MVP</span></div>
<div class="skill-card"><div><div class="skill-name">🌍 Ancestry PCA</div><div class="skill-desc">PCA decomposition vs SGDP reference panel (345 samples, 164 global populations). Publication-quality figures.</div></div><span class="skill-badge badge-mvp">MVP</span></div>
<div class="skill-card"><div><div class="skill-name">📚 Semantic Similarity</div><div class="skill-desc">Semantic Isolation Index for 175 GBD diseases from 13.1M PubMed abstracts using PubMedBERT embeddings.</div></div><span class="skill-badge badge-mvp">MVP</span></div>
<div class="skill-card"><div><div class="skill-name">⚖️ Equity Scorer</div><div class="skill-desc">HEIM diversity metrics from VCF/ancestry data. Heterozygosity, FST, PCA, and composite equity scores.</div></div><span class="skill-badge badge-mvp">MVP</span></div>
<div class="skill-card"><div><div class="skill-name">🥗 NutriGx Advisor</div><div class="skill-desc">Nutrigenomics report: 40 SNPs, 13 nutrient domains, personalised dietary recommendations. Community-contributed.</div></div><span class="skill-badge badge-mvp">MVP</span></div>
<div class="skill-card"><div><div class="skill-name">🧬 Metagenomics Profiler</div><div class="skill-desc">Microbial community profiling with Kraken2/Bracken. Alpha diversity, taxonomic composition, abundance plots.</div></div><span class="skill-badge badge-mvp">MVP</span></div>
<div class="skill-card"><div><div class="skill-name">🧬 Genome Compare</div><div class="skill-desc">Compare two genotypes: IBS relatedness score, ancestry estimation, and population-level context from 23andMe data.</div></div><span class="skill-badge badge-mvp">MVP</span></div>
<div class="skill-card"><div><div class="skill-name">🧬 VCF Annotator</div><div class="skill-desc">Variant annotation with VEP, ClinVar, gnomAD + ancestry context.</div></div><span class="skill-badge badge-planned">Planned</span></div>
<div class="skill-card"><div><div class="skill-name">📄 Lit Synthesizer</div><div class="skill-desc">PubMed/bioRxiv search with LLM summarisation and citation graphs.</div></div><span class="skill-badge badge-planned">Planned</span></div>
<div class="skill-card"><div><div class="skill-name">🔬 scRNA Orchestrator</div><div class="skill-desc">Scanpy automation: QC, clustering, DE analysis, visualisation.</div></div><span class="skill-badge badge-planned">Planned</span></div>
</div>
</div>
</section>
<section id="showcase">
<div class="section-inner">
<div class="section-label">In Production</div>
<div class="section-title">ClawBio skills, running in conversation</div>
<p class="section-sub">ClawBio skills aren't just CLI tools — they power live AI agents that talk to real users every day.</p>
<div class="showcase-card">
<img class="showcase-avatar" src="roboterri-avatar.png" alt="RoboTerri avatar">
<div>
<div class="showcase-name">RoboTerri</div>
<div class="showcase-role">Telegram AI Agent</div>
<div class="showcase-desc">A bioinformatics intelligence agent on Telegram — inspired by Professor Teresa K. Attwood, a pioneer of bioinformatics education and research. Run pharmacogenomics reports from your own genetic data. Snap a photo of your medication, get personalised dosage guidance. All local-first, all reproducible.</div>
<div class="showcase-skills">
<span class="showcase-skill">PharmGx Reporter</span>
<span class="showcase-skill">NutriGx Advisor</span>
<span class="showcase-skill">Genome Compare</span>
<span class="showcase-skill">Equity Scorer</span>
<span class="showcase-skill">Drug Photo Lookup</span>
<span class="showcase-skill">Metagenomics</span>
</div>
</div>
</div>
</div>
</section>
<section id="community">
<div class="section-inner">
<div class="section-label">Community</div>
<div class="section-title">Wanted: skills from the community</div>
<p class="section-sub">If you work with genomics, proteomics, metabolomics, imaging, or clinical data — wrap your pipeline as a skill.</p>
<div class="community-grid">
<div class="community-card"><div class="skill-name">claw-gwas</div><div class="skill-desc">PLINK/REGENIE automation — Statistical genetics</div></div>
<div class="community-card"><div class="skill-name">claw-metagenomics</div><div class="skill-desc">Kraken2/MetaPhlAn wrapper — Microbiome</div></div>
<div class="community-card"><div class="skill-name">claw-acmg</div><div class="skill-desc">Clinical variant classification — Clinical genomics</div></div>
<div class="community-card"><div class="skill-name">claw-pathway</div><div class="skill-desc">GO/KEGG enrichment — Functional genomics</div></div>
<div class="community-card"><div class="skill-name">claw-phylogenetics</div><div class="skill-desc">IQ-TREE/RAxML automation — Evolutionary biology</div></div>
<div class="community-card"><div class="skill-name">claw-proteomics</div><div class="skill-desc">MaxQuant/DIA-NN — Proteomics</div></div>
<div class="community-card"><div class="skill-name">claw-spatial</div><div class="skill-desc">Visium/MERFISH — Spatial transcriptomics</div></div>
<div class="community-card" style="display:flex;align-items:center;justify-content:center;border-style:dashed;"><div style="text-align:center;color:var(--text-muted);"><div style="font-size:1.5rem;margin-bottom:0.4rem;">+</div><div class="skill-name">Your skill here</div></div></div>
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<div style="margin-top:2rem;"><a class="btn btn-secondary" href="https://github.com/ClawBio/ClawBio/blob/main/CONTRIBUTING.md" target="_blank">📖 Read the contribution guide</a></div>
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<h2>Get started in 30 seconds</h2>
<p>Clone, install, run — every skill includes demo data.</p>
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<span style="color:#8b949e"># Clone and install</span><br>
<span style="color:var(--accent2)">git clone https://github.com/ClawBio/ClawBio.git && cd ClawBio</span><br>
<span style="color:var(--accent2)">pip install -r requirements.txt</span><br><br>
<span style="color:#8b949e"># Run a skill with demo data</span><br>
<span style="color:var(--accent2)">python clawbio.py run pharmgx --demo</span><br><br>
<span style="color:#8b949e"># Or run with your own data</span><br>
<span style="color:var(--accent2)">python clawbio.py run pharmgx --input my_23andme.txt</span>
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<a class="btn btn-primary" href="https://github.com/ClawBio/ClawBio" target="_blank">⭐ Star on GitHub</a>
<a class="btn btn-secondary" href="https://github.com/ClawBio/ClawBio/blob/main/README.md" target="_blank">📄 Full documentation</a>
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<a href="https://github.com/ClawBio/ClawBio" target="_blank">GitHub</a>
<a href="https://github.com/ClawBio/ClawBio/blob/main/CONTRIBUTING.md" target="_blank">Contributing</a>
<a href="https://github.com/ClawBio/ClawBio/blob/main/LICENSE" target="_blank">MIT License</a>
<a href="mailto:mc@manuelcorpas.com">Contact</a>
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<p>🦖 ClawBio — MIT License · Built by <a href="https://www.linkedin.com/in/manuelcorpas" target="_blank">Manuel Corpas</a> and the community</p>
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